sandy beach Posted May 15, 2020 Report Share Posted May 15, 2020 Monoclonal antibody therapeutics has been around for 30 years. In fact everyone of us who was breast fed received antibodies from our mother's milk which protected us from pathogens until we developed our own functioning adaptive immune system. Giving plasma from recovered patients to infected patients has already be proven effective. It works because it transfers IgG from a recovered patient to a sick patient which binds the virus and leads to its removal. The problem there is plasma donations are few and you may not get enough of the type of antibody that will work best i.e. that has a high enough titer and specificity and can inactivate the virus. Monoclonal antibody therapeutics solves this because we can test millions of antibodies and find the one that is 100% effective and produce in cheaply in unlimited amounts. There is a downside to every therapy and the major downside here is that immunity is not permanent because IgG antibodies don't last forever. So you would need to periodically get another dose. The other issue is once the disease is too advanced and you already have organ damage or a cytokine storm it isn't going to help. So you either need to take it early in the coarse of disease or take it as a prophylactic. Antibodies are produced by B Cells and when a B Cell with an IgM surface antibody binds successfully to the virus (hopefully to the S Protein) it starts to multiply into many plasma B Cells that produce plasma IgG which have the same binding domains. Once IgG binds to the S protein on the surface of the virus the virus is marked for destruction. IgG looks like the letter Y and is composed of two light chains and two heavy chains. Only the heavy chains differ between IgM and IgG. It is the light chains on the "arm" of the Y that bind specifically to the S protein. https://en.wikipedia.org/wiki/Antibody https://en.wikipedia.org/wiki/Monoclonal_antibody_therapy A paper regarding the research is being submitted to a peer reviewed journal: https://investors.sorrentotherapeutics.com/news-releases/news-release-details/sti-1499-potent-anti-sars-cov-2-antibody-demonstrates-ability There are several companies with candidate monoclonal antibodies. Which will be FDA approved first will be worth watching but with anything involving the FDA it will take time and involve several trials. https://www.biorxiv.org/content/10.1101/2020.03.11.987958v1.full.pdf My sister has already produced antibodies against SARS-CoV-2 in cows. Why? because in the third world consumption of cow colostrum containing antibodies may cheaply offer some immunity to the virus without medical intervention. Link to comment Share on other sites More sharing options...
sandy beach Posted May 15, 2020 Report Share Posted May 15, 2020 GE back to 1991 levels. Link to comment Share on other sites More sharing options...
MisFit Kid Posted May 15, 2020 Report Share Posted May 15, 2020 9 minutes ago, sandy beach said: GE back to 1991 levels. Jack Welch is still smiling.........(passed away in March 2020) in 2001.......severance payment of $417 million >: He had a book called "Winning"....... Link to comment Share on other sites More sharing options...
MisFit Kid Posted May 16, 2020 Report Share Posted May 16, 2020 Bundesliga plays tomorrow.......⚽ FOX sports is televising.........Some others are streaming...... I Hope This Turns Out Good! Link to comment Share on other sites More sharing options...
fxfox Posted May 16, 2020 Report Share Posted May 16, 2020 😂😂😂 That‘s exactly my humor. Effing awesome! Link to comment Share on other sites More sharing options...
DrStool Posted May 17, 2020 Author Report Share Posted May 17, 2020 What's the story with beta blockers and COVID19? I know there are those that believe it helps to block the virus from binding to the cells. Any investigational studies? Or will this be a non starter because it's too easy, dirt cheap, and widely available? Link to comment Share on other sites More sharing options...
aussiebear Posted May 17, 2020 Report Share Posted May 17, 2020 1 hour ago, DrStool said: What's the story with beta blockers and COVID19? I know there are those that believe it helps to block the virus from binding to the cells. Any investigational studies? Or will this be a non starter because it's too easy, dirt cheap, and widely available? I think the current hypothesis is that ARBs could enhance COVID-19 reactions: "The connection between ARBs and COVID-19 Professor Murray Esler is the senior director of the Baker Heart and Diabetes Institute and consultant cardiologist at the Alfred Hospital Melbourne and Adjunct Professor of Medicine at Monash University. Professor Esler told newsGP he first became concerned about ARBs and COVID-19 when talking to his daughter, a public health physician in the Northern Territory, a few weeks ago. ‘The first clue was really that severe COVID-19 infection was more common in hypertension, and hypertensive patients are really not predisposed to infection at all, so that was very odd,’ he said. ‘So that suggested perhaps this predisposition to severe COVID-19 infection in hypertension could possibly be a drug effect mediated by ARBs which upregulates ACE-2, and potentially predisposes to infectivity but also in particular, severe infection.’ Professor Esler has been in contact with colleagues in Lombardy, Italy, who are currently exploring it further." https://www1.racgp.org.au/newsgp/clinical/ace-inhibitors-arbs-and-covid-19-what-gps-need-to Link to comment Share on other sites More sharing options...
DrStool Posted May 17, 2020 Author Report Share Posted May 17, 2020 That's old news. The latest is that there seems to be some benefit based on tracking of Wuhan patients. Link to comment Share on other sites More sharing options...
aussiebear Posted May 17, 2020 Report Share Posted May 17, 2020 ok, haven't heard about that .. Link to comment Share on other sites More sharing options...
fxfox Posted May 17, 2020 Report Share Posted May 17, 2020 Powell on CBS „60 minutes“ tonight. https://www.marketwatch.com/discover?url=https%3A%2F%2Fwww.marketwatch.com%2Famp%2Fstory%2Fguid%2F6a8a5232-9852-11ea-96ab-1af50516e038&link=sfmw_tw#https://www.marketwatch.com/amp/story/guid/6a8a5232-9852-11ea-96ab-1af50516e038?mod=dist_amp_social Link to comment Share on other sites More sharing options...
sandy beach Posted May 17, 2020 Report Share Posted May 17, 2020 Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19. https://www.ncbi.nlm.nih.gov/pubmed/32302265 Retrospective, multicenter study of 1128 adult pts with HTN diagnosed with COVID19: Taking ACEI/ARB: 188 Not Taking ACEI/ARB: 940 Unadjusted 28d Mortality: No ACEI/ARB: 9.8% ACEI/ARB: 3.7% P = 0.01 ACEI/ARB also associated with decreased mortality compared to other antihypertensive drugs (aHR 0.30; 95% CI 0.12 to 0.70; p = 0.01 Bottom Line: Inpt use of ACEI/ARB was ASSOCIATED with lower risk of all-cause 28d mortality compared with ACEI/ARB non-users. Link to comment Share on other sites More sharing options...
DrStool Posted May 17, 2020 Author Report Share Posted May 17, 2020 Ok. Not sure what that said but sounded good. ARB is beta blockers? Link to comment Share on other sites More sharing options...
Jimi Posted May 18, 2020 Report Share Posted May 18, 2020 5 hours ago, fxfox said: Powell on CBS „60 minutes“ tonight. https://www.marketwatch.com/discover?url=https%3A%2F%2Fwww.marketwatch.com%2Famp%2Fstory%2Fguid%2F6a8a5232-9852-11ea-96ab-1af50516e038&link=sfmw_tw#https://www.marketwatch.com/amp/story/guid/6a8a5232-9852-11ea-96ab-1af50516e038?mod=dist_amp_social Doc would be a good guest host for such an episode. Link to comment Share on other sites More sharing options...
Jimi Posted May 18, 2020 Report Share Posted May 18, 2020 There'd be a lot of **BEEPS** as Doc cursed his way through the episode. Powell would say something dishonest or stupid. Doc would lose his mind and start hollering. Stoolies would cheer their televisions. Link to comment Share on other sites More sharing options...
MisFit Kid Posted May 18, 2020 Report Share Posted May 18, 2020 24 minutes ago, Jimi said: There'd be a lot of **BEEPS** as Doc cursed his way through the episode. Powell would say something dishonest or stupid. Doc would lose his mind and start hollering. Stoolies would cheer their televisions. I am smiling just thinking about it......🤣 Link to comment Share on other sites More sharing options...
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