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sandy beach

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Everything posted by sandy beach

  1. This paper describes the renin–angiotensin system and activity of ACE2 in SARS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079827/ The role of heme and iron in Lung injury in ARDS: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796260/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772369/ https://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A2079
  2. Here are a couple of papers about ADE: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290032/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057165/
  3. The first statement is regarding the cytokine storm I described above. He's talking about the same experiment I was. The virus SARS infects innate immune cells like dendritic cells which in turn over express signal molecules called cytokines. In vaccinated people the secretion of cytokines is too high and it makes the immune system overreact which in turn causes acute respiratory syndrome (ARDS) and lung injury resulting in death. Lung injury itself is a complex topic as in includes the renin–angiotensin system and activity of ACE2 as well and injury by heme groups (which wasn’t fully understo
  4. We have been working on a SARS vaccine since 2002 with limited success. As of 2019 they were making some progress so we can learn from that since SARS-CoV-2 is very similar. But it has been extremely difficult. One the earlier vaccines created antibodies as expected but upon challenge by live virus the inoculated animals died a terrible death due to cytokine storms. Another attempt used live attenuated virus which was successful until it reverted to wild type and cause the infection we were trying to prevent. Now we have a new improved live attenuated virus - please you can try it before me B
  5. I'm hoping most of them show back up when the S&P retests 666.
  6. I certainly hope for your sake and your families sake that you are immune! My wife's sister in Santa Clara County has it and she is stable on oxygen (verified with rtPCR). I believe two of my sisters may have gotten it with their husbands in Northern CO. The symptoms were very similar but luckily they all recovered. My wife and I are trying our best to not get it - we don't even go shopping. Locked in since late January.
  7. We are collecting a lot more serology samples - so that error bars will get narrower over time. But it does appear the cat is out of the bag in the U.S. Santa Clara got infected very early but we also were one of the very first to close down.
  8. First data is out for the Stanford Serology study of Santa Clara county. They found the actual infection rate is 50-85 times greater than the number of confirmed cases. That implies a 2.49%-4.16% infection rate. In rural Telluride area is was 0.5%. In a random sample of pregnant women in NYC it was 15%. So that gives us our first estimate for the range across the US. Given that we have 678K confirmed cases that would put the actual infected range at 34-58 million in the states right now. Still tough to calculate case fatality rate as deaths lag by 17 days on average that we know of.
  9. In the national pandemic plan published in 2005 the states were supposed to prepare including with a fund. California has such a fund. I doubt it will be a enough but still a very good start. A lot of states do not. States like Illinois are going to have a terrible time unless they get bailed out. Of interest the first documentary on COVID19 / SARS-CoV-2 - one hour long - worth a gander:
  10. They won't even need to buy up the little companies. Just wait for the auction of their assets, contract with their landlord and pick up all their employees. The rest of the small companies are going to be black holes. I saw that go on after the dot com crash here. This is going to be going on all around the world
  11. Brookings bringing out 'ol Ben Bernanke from the closet today:
  12. Janet Yellen interview - she slams share buy back and debt with poor underwriting (~15m). She doesn't see inflation coming (~30m).
  13. Mr. Armstrong if this is a hoax than why did the CCP literally shown down a city of 16 million people and weld citizens into their apartment buildings? Is the CCP run by the "deep state." And every other country of Korea to Brazil is in on the scam? Perhaps dementia has set in because I can't understand how anyone could logically conclude we are not in a pandemic.
  14. I sure am glad as hell I didn't go short on Friday. I would have been road kill.
  15. My call for a dive Monday - not so good. I still think we are range bound and will retest the lows at some point.
  16. How did I get so lucky to be around so many bright people. Jimi you essay kicked ass and Doc your deconstruction gives me pause. From my world - In America 38 states are already reporting serological results (i.e. antybody tests to SARS-Cov-2) with less than 5% infection. NY 36% NJ 42% LA 25% MA CT MI 20% DC 15% WA 8% IL CO 16% PA 12% God I love being an American were we can openly share results in real time. More data to come. These are very small samples so far. We're just getting warmed up on this methodology. But this will be key to killing this epidemic. I can't stress out important
  17. A lot of these tests are 90% accurate. So they will still leave a lot of infected people in the workforce. N95 masks are what they really need to be using.
  18. The Russell 2000 is plummeting down 5% and the stool crew is talking football. This bear has further to go.
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